Microbial Diversity

Bacterial and Fungal Diversity

Traditional qPCR and pathogen array approaches are limited to a pre-defined set of approximately 25 to 40 microorganisms. These technologies can only detect what they are designed for to investigate. However, the diversity of microbial etiologies of diseases like sepsis, meningitis, endocarditis, or arthritis is significantly higher, including more than 130 bacterial and fungal strains. Broad-range detection and identification approaches like 16S rRNA gene PCR are potentially useful to analyze any pathogen present in a clinical sample. By the enrichment of pathogen DNA from samples, SepsiTest™ overcomes the common constraints of broad-range approaches, i.e., low sensitivity and specificity by nonspecific signal generation from human sequences. As a result, an up to 40,000-times higher sensitivity is obtained as compared to conventional 16S approaches.
Based on Molzym’s SepsiTest™ technology, pathogen DNA is available to next-generation sequencing (NGS) technologies. We deliver the following information:
  • Identification of the most abundant microbes in clinical samples
  • Drug treatment-related changes in microbial colonization
  • Microbial diversity in biofilms
  • Pathogen diversity in animal models

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