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NGS
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Report on the 2nd Conference on Clinical Metagenomics

13 August 2018

Metagenomic sequencing is used to recover information regarding clinically relevant infections. In their report, Ruppé & Schrenzel summarise last year’s 2nd International Conference on Clinical Metagenomics (ICCMg2). This post focusses on the current status, experiences, diagnostic use and clinical impact of sample treatment.

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Molecular Diagnostics
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Diagnosis of Culture-Negative Infective Endocarditis

03 August 2018

Identification of aetiologies of infective endocarditis is crucial for initiation of targeted antibiotic treatment and patient outcome, but culture often fails. Marsch and his colleagues analysed 46 heart valves with negative or inconsistent culture results by 16S/18S rDNA PCR. In 7 patients, PCR results led to the change of the antibiotic regime.

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Molzym Inside
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Visit Molzym at the AACC Annual Meeting in Chicago, IL

23 July 2018

The 70th AACC Annual Scientific Meeting & Clinical Lab Expo is the largest global scientific conference in laboratory medicine. Molzym will be exhibiting their innovative products for rapid culture-independent molecular diagnosis of microbes focussing on unique solutions for microbial DNA enrichment from clinical specimens and DNA-free PCR assays.

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Molecular Diagnostics
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Unbiased PCR and Sequencing of Blood Stream Infections

18 July 2018

Rapid diagnosis of sepsis pathogens is crucial for an early targeted antibiotic treatment and improved outcome of patients. Blood culture needs days until pathogen identification and often stays negative. Tkadlec et al. discuss the pros and cons of broad-range 16S rDNA PCR and sequencing on the basis of blood sample results of 330 patients.

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Molzym Inside
Fungitect logo

EU-Funded Project on Invasive Fungal Disease Detection

06 July 2018

Invasive fungal disease is a major cause of morbidity and mortality in immuno-compromised patients. In a FP7 project of the European Commission, Molzym partners with 5 institutions from 4 countries to develop and evaluate in multi-centre clincial studies fast DNA, enzymatic and protein-based assays.

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Automation
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SelectNA™plus - Robotic Pathogen DNA Extraction System

27 June 2018

SelectNA™plus is the ‘Selective extraction of microbial Nucleic Acids’ from mixtures including host and microbial cells providing a ‘plus’ benefit by walk-away automated processing of clinical samples. This highly enriched microbial DNA guarantees highest analytical performance in research and routine diagnosis.

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Molzym Inside
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Molzym - 15 Years Expertise in Molecular Diagnostics

15 June 2018

Molzym turns 15 years this month. Over the years, Molzym won reputation as a specialist in the fast molecular diagnosis of microbial pathogens without the need of cultivation. Our expertise in unique DNA extraction solutions and the supply of DNA-free amplification reagents supports the standardisation of qPCR, gene clone library and NGS assaying.

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Molzym Inside
Fapic

Molzym Partners EU-Funded Project on Fast Pathogen ID

06 June 2018

Molzym partners EU Horizon 2020 project “Fast Assay for Pathogen Identification and Characterization” (FAPIC). Ten members from 7 countries joined to develop and clinically evaluate fast molecular assays for the identification of bacterial pathogens. Health system-relevant issues led to the prototyping of new automated diagnostic systems.

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Pathogen DNA Isolation
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Applications of MolYsis™

29 May 2018

Remove your host DNA for increased sensitivity for detection of microbes in a great variety of specimens. Here, we provide a collection of applications of MolYsis™ sample pre-treatment in combination with various analytical methods, including next generation sequencing, PCR and Real-time PCR, DNA arrays and amplicon cloning.

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Pathogen DNA Isolation
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One Protocol for Preparation of Bacterial and Fungal DNA

24 May 2018

Efficient cell destruction is a key problem of microbial DNA isolation. As a component of Molzym's DNA extraction kits, the BugLysis reagent ensures degradation of the very different cell walls among prokaryotes and fungi. The high efficiency of BugLysis becomes obvious when considering that 1,330 species have been identified in studies and assaying so far.

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Molzym Inside
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Thank You for Visiting Us at ECCMID

15 May 2018

The Molzym-Team was delighted to participate and exhibit at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) that took place in Madrid, Spain, from 21st to 24th of April 2018. Here we want to share some impressions and highlights of this year’s ECCMID with you.

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NGS
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Standardised Method for Infection Diagnosis with NGS

08 May 2018

In a poster presentation at this year’s ECCMID congress, Edelmann et al. [1] compared 4 DNA extraction kits and the influence of human DNA removal for use in microbiome analysis. Additionally, two master mixes were tested for bacterial DNA contamination. An efficient workflow towards a standardised use of NGS in infection diagnosis was proposed.

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